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Infection and Immunity, January 2006, p. 740-743, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.740-743.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Contribution of Sialic Acid-Binding Adhesin to Pathogenesis of Experimental Endocarditis Caused by Streptococcus gordonii DL1

Yukihiro Takahashi,1* Eizo Takashima,1 Kisaki Shimazu,2 Hisao Yagishita,3 Takaaki Aoba,3 and Kiyoshi Konishi1

Department of Microbiology,1 Department of Pediatric Dentistry,2 Department of Pathology, Nippon Dental University School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan3

Received 18 May 2005/ Returned for modification 29 August 2005/ Accepted 21 October 2005

An insertional mutation in hsa, the gene encoding the sialic acid-binding adhesin of Streptococcus gordonii DL1, resulted in a significant reduction of the infection rate of the organism and an inflammatory reaction in the rat aortic valve with experimental endocarditis, suggesting that the adhesin contributes to the infectivity of the organism for heart valves.

* Corresponding author. Mailing address: Department of Microbiology, Nippon Dental University School of Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. Phone: 81-3-3261-8763. Fax: 81-3-3264-8399. E-mail: biseibut{at}tky.ndu.ac.jp.

Editor: V. J. DiRita

Infection and Immunity, January 2006, p. 740-743, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.740-743.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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