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Infection and Immunity, January 2006, p. 765-768, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.765-768.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Listeria monocytogenes 10403S HtrA Is Necessary for Resistance to Cellular Stress and Virulence

Rebecca L. Wilson, Lindsay L. Brown, Dana Kirkwood-Watts, Travis K. Warren, S. Amanda Lund, David S. King, Kevin F. Jones, and Dennis E. Hruby*

SIGA Technologies, Inc., Corvallis, Oregon 97330

Received 20 May 2005/ Returned for modification 14 September 2005/ Accepted 26 October 2005

The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.

* Corresponding author. Mailing address: SIGA Technologies, 4575 NW Research Way, Corvallis, OR 97330. Phone: (541) 753-2000. Fax: (541) 753-9999. E-mail: dhruby{at}sgph.com.

Editor: V. J. DiRita

Infection and Immunity, January 2006, p. 765-768, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.765-768.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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