This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goon, S.
Right arrow Articles by Guerry, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goon, S.
Right arrow Articles by Guerry, P.

 Previous Article  |  Next Article 

Infection and Immunity, January 2006, p. 769-772, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.769-772.2006

A {sigma}28-Regulated Nonflagella Gene Contributes to Virulence of Campylobacter jejuni 81-176

Scarlett Goon,1 Cheryl P. Ewing,1 Maria Lorenzo,2 Dawn Pattarini,1 Gary Majam,1 and Patricia Guerry1*

Enteric Diseases Department, Naval Medial Research Center, Silver Spring, Maryland 20910,1 Food and Drug Administration MOD1, Beltsville, Maryland2

Received 9 August 2005/ Returned for modification 19 September 2005/ Accepted 25 October 2005

A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.

* Corresponding author. Mailing address: Enteric Diseases Dept., Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-7662. Fax: (301) 319-7679. E-mail: guerryp{at}nmrc.navy.mil.

Editor: J. T. Barbieri

Infection and Immunity, January 2006, p. 769-772, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.769-772.2006




This article has been cited by other articles:

  • Ewing, C. P., Andreishcheva, E., Guerry, P. (2009). Functional Characterization of Flagellin Glycosylation in Campylobacter jejuni 81-176. J. Bacteriol. 191: 7086-7093 [Abstract] [Full Text]  
  • Joslin, S. N., Hendrixson, D. R. (2009). Activation of the Campylobacter jejuni FlgSR Two-Component System Is Linked to the Flagellar Export Apparatus. J. Bacteriol. 191: 2656-2667 [Abstract] [Full Text]  
  • Elliott, K. T., Zhulin, I. B., Stuckey, J. A., DiRita, V. J. (2009). Conserved Residues in the HAMP Domain Define a New Family of Proposed Bipartite Energy Taxis Receptors. J. Bacteriol. 191: 375-387 [Abstract] [Full Text]  
  • Sterzenbach, T., Bartonickova, L., Behrens, W., Brenneke, B., Schulze, J., Kops, F., Chin, E. Y., Katzowitsch, E., Schauer, D. B., Fox, J. G., Suerbaum, S., Josenhans, C. (2008). Role of the Helicobacter hepaticus Flagellar Sigma Factor FliA in Gene Regulation and Murine Colonization. J. Bacteriol. 190: 6398-6408 [Abstract] [Full Text]  
  • Baqar, S., Applebee, L. A., Gilliland, T. C. Jr., Lee, L. H., Porter, C. K., Guerry, P. (2008). Immunogenicity and Protective Efficacy of Recombinant Campylobacter jejuni Flagellum-Secreted Proteins in Mice. Infect. Immun. 76: 3170-3175 [Abstract] [Full Text]  
  • Yun, J., Jeon, B., Barton, Y.-W., Plummer, P., Zhang, Q., Ryu, S. (2008). Role of the DksA-Like Protein in the Pathogenesis and Diverse Metabolic Activity of Campylobacter jejuni. J. Bacteriol. 190: 4512-4520 [Abstract] [Full Text]  
  • Galkin, V. E., Yu, X., Bielnicki, J., Heuser, J., Ewing, C. P., Guerry, P., Egelman, E. H. (2008). Divergence of Quaternary Structures Among Bacterial Flagellar Filaments. Science 320: 382-385 [Abstract] [Full Text]  
  • Joslin, S. N., Hendrixson, D. R. (2008). Analysis of the Campylobacter jejuni FlgR Response Regulator Suggests Integration of Diverse Mechanisms To Activate an NtrC-Like Protein. J. Bacteriol. 190: 2422-2433 [Abstract] [Full Text]  
  • Claret, L., Miquel, S., Vieille, N., Ryjenkov, D. A., Gomelsky, M., Darfeuille-Michaud, A. (2007). The Flagellar Sigma Factor FliA Regulates Adhesion and Invasion of Crohn Disease-associated Escherichia coli via a Cyclic Dimeric GMP-dependent Pathway. J. Biol. Chem. 282: 33275-33283 [Abstract] [Full Text]  
  • Kamal, N., Dorrell, N., Jagannathan, A., Turner, S. M., Constantinidou, C., Studholme, D. J., Marsden, G., Hinds, J., Laing, K. G., Wren, B. W., Penn, C. W. (2007). Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the {sigma}54-dependent regulon in Campylobacter jejuni. Microbiology 153: 3099-3111 [Abstract] [Full Text]  
  • Poly, F., Ewing, C., Goon, S., Hickey, T. E., Rockabrand, D., Majam, G., Lee, L., Phan, J., Savarino, N. J., Guerry, P. (2007). Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament. Infect. Immun. 75: 3859-3867 [Abstract] [Full Text]  
  • Poly, F., Read, T., Tribble, D. R., Baqar, S., Lorenzo, M., Guerry, P. (2007). Genome Sequence of a Clinical Isolate of Campylobacter jejuni from Thailand. Infect. Immun. 75: 3425-3433 [Abstract] [Full Text]  
  • Johanesen, P. A., Dwinell, M. B. (2006). Flagellin-Independent Regulation of Chemokine Host Defense in Campylobacter jejuni-Infected Intestinal Epithelium.. Infect. Immun. 74: 3437-3447 [Abstract] [Full Text]  
  • Kanipes, M. I., Papp-Szabo, E., Guerry, P., Monteiro, M. A. (2006). Mutation of waaC, Encoding Heptosyltransferase I in Campylobacter jejuni 81-176, Affects the Structure of both Lipooligosaccharide and Capsular Carbohydrate. J. Bacteriol. 188: 3273-3279 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»