This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goon, S. Articles by Guerry, P. Search for Related Content PubMed PubMed Citation Articles by Goon, S. Articles by Guerry, P.

 Previous Article  |  Next Article 

Infection and Immunity, January 2006, p. 769-772, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.769-772.2006

A ²⁸-Regulated Nonflagella Gene Contributes to Virulence of Campylobacter jejuni 81-176

Enteric Diseases Department, Naval Medial Research Center, Silver Spring, Maryland 20910,¹ Food and Drug Administration MOD1, Beltsville, Maryland²

Received 9 August 2005/ Returned for modification 19 September 2005/ Accepted 25 October 2005

A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.

Editor: J. T. Barbieri

This article has been cited by other articles:

• Baqar, S., Applebee, L. A., Gilliland, T. C. Jr., Lee, L. H., Porter, C. K., Guerry, P. (2008). Immunogenicity and Protective Efficacy of Recombinant Campylobacter jejuni Flagellum-Secreted Proteins in Mice. Infect. Immun. 76: 3170-3175 [Abstract] [Full Text]  
• Yun, J., Jeon, B., Barton, Y.-W., Plummer, P., Zhang, Q., Ryu, S. (2008). Role of the DksA-Like Protein in the Pathogenesis and Diverse Metabolic Activity of Campylobacter jejuni. J. Bacteriol. 190: 4512-4520 [Abstract] [Full Text]  
• Galkin, V. E., Yu, X., Bielnicki, J., Heuser, J., Ewing, C. P., Guerry, P., Egelman, E. H. (2008). Divergence of Quaternary Structures Among Bacterial Flagellar Filaments. Science 320: 382-385 [Abstract] [Full Text]  
• Joslin, S. N., Hendrixson, D. R. (2008). Analysis of the Campylobacter jejuni FlgR Response Regulator Suggests Integration of Diverse Mechanisms To Activate an NtrC-Like Protein. J. Bacteriol. 190: 2422-2433 [Abstract] [Full Text]  
• Claret, L., Miquel, S., Vieille, N., Ryjenkov, D. A., Gomelsky, M., Darfeuille-Michaud, A. (2007). The Flagellar Sigma Factor FliA Regulates Adhesion and Invasion of Crohn Disease-associated Escherichia coli via a Cyclic Dimeric GMP-dependent Pathway. J. Biol. Chem. 282: 33275-33283 [Abstract] [Full Text]  
• Kamal, N., Dorrell, N., Jagannathan, A., Turner, S. M., Constantinidou, C., Studholme, D. J., Marsden, G., Hinds, J., Laing, K. G., Wren, B. W., Penn, C. W. (2007). Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the {sigma}54-dependent regulon in Campylobacter jejuni. Microbiology 153: 3099-3111 [Abstract] [Full Text]  
• Poly, F., Ewing, C., Goon, S., Hickey, T. E., Rockabrand, D., Majam, G., Lee, L., Phan, J., Savarino, N. J., Guerry, P. (2007). Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament. Infect. Immun. 75: 3859-3867 [Abstract] [Full Text]  
• Poly, F., Read, T., Tribble, D. R., Baqar, S., Lorenzo, M., Guerry, P. (2007). Genome Sequence of a Clinical Isolate of Campylobacter jejuni from Thailand. Infect. Immun. 75: 3425-3433 [Abstract] [Full Text]  
• Johanesen, P. A., Dwinell, M. B. (2006). Flagellin-Independent Regulation of Chemokine Host Defense in Campylobacter jejuni-Infected Intestinal Epithelium.. Infect. Immun. 74: 3437-3447 [Abstract] [Full Text]  
• Kanipes, M. I., Papp-Szabo, E., Guerry, P., Monteiro, M. A. (2006). Mutation of waaC, Encoding Heptosyltransferase I in Campylobacter jejuni 81-176, Affects the Structure of both Lipooligosaccharide and Capsular Carbohydrate. J. Bacteriol. 188: 3273-3279 [Abstract] [Full Text]