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Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8⁺ T Cells Requires the Presence of Cognate Antigen

Rosalind Polley ,^1,, Simona Stager,^1,,¶ Sara Prickett,^2,|| Asher Maroof,^1, Soombul Zubairi,^1, Deborah F. Smith,^2, and Paul M. Kaye^1*

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT United Kingdom,¹ Wellcome Trust Laboratories for Molecular Parasitology, Department of Biological Sciences, Imperial College London, London, SW7 2AZ United Kingdom²

Received 26 July 2005/ Accepted 13 September 2005

CD8⁺ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8⁺ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8⁺ T cells is strictly dependent upon the presence of cognate antigen.

Editor: J. L. Flynn

These authors contributed equally to this work.

Present address: Lymphocyte Biology Section, Laboratory of Immunology, NIAID/National Institutes of Health, Bethesda, MD 20892.

^¶ Present address: Division of Biomedical Sciences, Johns Hopkins in Singapore, 31 Biopolis Way, 02-01 The Nanos, Singapore 138669, Republic of Singapore.

^|| Present address: Division of Infection and Immunity, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia.

Present address: Immunology and Infection Unit, Dept. of Biology, University of York, P.O. Box 373, York, YO10 5YW United Kingdom.

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