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Infection and Immunity, January 2006, p. 777-780, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.777-780.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immunization with Persistent Attenuated {Delta}lpg2 Leishmania major Parasites Requires Adjuvant To Provide Protective Immunity in C57BL/6 Mice

Chahnaz Kébaïer,1 Jude E. Uzonna,1,{dagger} Stephen M. Beverley,2 and Phillip Scott1*

Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104,1 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 631102

Received 8 June 2005/ Returned for modification 10 August 2005/ Accepted 10 October 2005

Leishmania major parasites lacking the GDP-mannose transporter, termed {Delta}lpg2 parasites, fail to induce disease in mice but persist long-term. We previously found that {Delta}lpg2 organisms protect BALB/c mice from virulent L. major challenge. In contrast, we report here that {Delta}lpg2 parasites induce protective immunity in C57BL/6 mice only when administered with CpG-containing oligodeoxynucleotides, indicating that parasite persistence alone is not sufficient to maintain protective immunity to L. major.

* Corresponding author. Mailing address: Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104. Phone: (215) 898-1602. Fax: (215) 573-7023. E-mail: pscott{at}vet.upenn.edu.

Editor: J. F. Urban, Jr.

{dagger} Present address: Department of Immunology, University of Manitoba, Winnipeg, MB, Canada, R3E 0W3.

Infection and Immunity, January 2006, p. 777-780, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.777-780.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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