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Infection and Immunity, January 2006, p. 786-789, Vol. 74, No. 1
0019-9567/06/$08.00+0 doi:10.1128/IAI.74.1.786-789.2006
Veerabadran Dheenadhayalan, and
Michael J. Brennan*
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
Received 16 August 2005/ Returned for modification 21 September 2005/ Accepted 4 October 2005
Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.
Present address: Scientific Review Program, Division of Extramural Activities, NIAID/NIH/DHHS, 6700B Rockledge Drive, Room 3238A, Bethesda, MD 20892.
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