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Infection and Immunity, January 2006, p. 786-789, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.786-789.2006

A PE Protein Expressed by Mycobacterium avium Is an Effective T-Cell Immunogen

Marcela Parra, Nathalie Cadieux, Thames Pickett,{dagger} Veerabadran Dheenadhayalan, and Michael J. Brennan*

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland

Received 16 August 2005/ Returned for modification 21 September 2005/ Accepted 4 October 2005

Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.

* Corresponding author. Mailing address: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892. Phone: (301) 496-9559. Fax: (301) 435-5675. E-mail: Brennan{at}cber.fda.gov.

Editor: J. L. Flynn

{dagger} Present address: Scientific Review Program, Division of Extramural Activities, NIAID/NIH/DHHS, 6700B Rockledge Drive, Room 3238A, Bethesda, MD 20892.

Infection and Immunity, January 2006, p. 786-789, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.786-789.2006




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