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Infection and Immunity, January 2006, p. 798-801, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.798-801.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka

Thilan Wickramarachchi,1 Prasad H. Premaratne,1 K. L. R. Lakshman Perera,2 Sumith Bandara,2 Clemens H. M. Kocken,3 Alan W. Thomas,3 Shiroma M. Handunnetti,2,{dagger} and Preethi V. Udagama-Randeniya1*

Department of Zoology, Faculty of Science, University of Colombo, Colombo 3, Sri Lanka,1 Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo 8, Sri Lanka,2 Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands3

Received 17 July 2004/ Returned for modification 24 August 2004/ Accepted 20 October 2005

Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exposure in areas where malaria was or was not endemic. A marked isotype switch to cytophilic (immunoglobulin G1 [IgG1]/IgG3) antibodies was evident with increasing exposure exclusively in residents from areas of endemicity.

* Corresponding author. Mailing address: Department of Zoology, Faculty of Science, University of Colombo, Colombo 3, Sri Lanka. Phone: 0094-011-2503399. Fax: 0094-011-2503148. E-mail: dappvr{at}sltnet.lk.

Editor: J. F. Urban, Jr.

{dagger} Present address: Institute of Biochemistry, Molecular Biology & Biotechnology, University of Colombo, Colombo 3, Sri Lanka.

Infection and Immunity, January 2006, p. 798-801, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.798-801.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gunasekera, A. M., Wickramarachchi, T., Neafsey, D. E., Ganguli, I., Perera, L., Premaratne, P. H., Hartl, D., Handunnetti, S. M., Udagama-Randeniya, P. V., Wirth, D. F. (2007). Genetic Diversity and Selection at the Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Locus in a Sri Lankan Population. Mol Biol Evol 24: 939-947 [Abstract] [Full Text]  


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