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Infection and Immunity, October 2006, p. 5602-5608, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00266-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Chlamydia trachomatis Infection Induces Cleavage of the Mitotic Cyclin B1

Zarine R. Balsara,1 Shahram Misaghi,2 James N. Lafave,1 and Michael N. Starnbach1*

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,1 Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 021422

Received 17 February 2006/ Returned for modification 6 April 2006/ Accepted 24 July 2006

The obligate intracellular pathogen Chlamydia trachomatis interferes with a number of host cell processes, including cytoskeletal organization, vesicular trafficking, and apoptosis. In this study we report that C. trachomatis-infected cells proliferate more slowly than uninfected cells, suggesting that C. trachomatis may also manipulate the eukaryotic cell cycle. We further demonstrate that C. trachomatis infection destabilizes specific cell cycle proteins involved in the G2/M transition. C. trachomatis-infected cells, compared to uninfected cells, have lower levels of cyclin-dependent kinase 1. Additionally, C. trachomatis infection induces an N-terminal truncation of the mitotic cyclin B1. Manipulation of the host cell cycle may represent a strategy used by C. trachomatis to ensure a stable environment conducive to bacterial growth and replication.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115. Phone: (617) 432-1873. Fax: (617) 738-7664. E-mail: starnbach{at}hms.harvard.edu.

Editor: J. B. Bliska

Infection and Immunity, October 2006, p. 5602-5608, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00266-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Paschen, S. A., Christian, J. G., Vier, J., Schmidt, F., Walch, A., Ojcius, D. M., Hacker, G. (2008). Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease. JCB 182: 117-127 [Abstract] [Full Text]  
  • Sun, J., Kintner, J., Schoborg, R. V. (2008). The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells. Microbiology 154: 1290-1299 [Abstract] [Full Text]  


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