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Infection and Immunity, October 2006, p. 5814-5819, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.01690-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mapping of the Plasmodium chabaudi Resistance Locus char2{dagger}

Enmoore Lin,1,2 Tony Pappenfuss,1 Rachel B. Tan,1 Danielle Senyschyn,1 Melanie Bahlo,1 Terence P. Speed,1 and Simon J. Foote1,3*

Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia,1 Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia,2 Menzies Research Institute, 17 Liverpool St., Hobart, Tasmania 7000, Australia3

Received 13 October 2005/ Returned for modification 24 January 2006/ Accepted 3 July 2006

Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain.

* Corresponding author. Mailing address: Menzies Research Institute, Private Bag 23, Hobart, TAS 7001, Australia. Phone: 61-3-9345-2611. Fax: 61-3-9347-0852. E-mail: foote{at}wehi.edu.au.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: J. F. Urban, Jr.

Infection and Immunity, October 2006, p. 5814-5819, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.01690-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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