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Infection and Immunity, October 2006, p. 6016-6019, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00671-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Acute Systemic Immune Activation following Conjunctival Exposure to Staphylococcal Enterotoxin B

Govindarajan Rajagopalan,1 Michele K. Smart,1 Robin Patel,2 and Chella S. David1*

Department of Immunology,1 Divisions of Infectious Diseases and Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, Minnesota 559052

Received 26 April 2006/ Returned for modification 26 June 2006/ Accepted 3 July 2006

Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the external eye. Using human leukocyte antigen class II transgenic mice, we show for the first time that conjunctival exposure to SEB can cause robust systemic immune activation.

* Corresponding author. Mailing address: Department of Immunology, Mayo Clinic College of Medicine, 200 First St., SW, Rochester, MN 55905. Phone: (507) 284-8180. Fax: (507) 266-0981. E-mail: davic4{at}mayo.edu.

Editor: J. T. Barbieri

Infection and Immunity, October 2006, p. 6016-6019, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00671-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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