This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rajagopalan, G.
Right arrow Articles by David, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rajagopalan, G.
Right arrow Articles by David, C. S.

 Previous Article  |  Next Article 

Infection and Immunity, October 2006, p. 6016-6019, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00671-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Acute Systemic Immune Activation following Conjunctival Exposure to Staphylococcal Enterotoxin B

Govindarajan Rajagopalan,1 Michele K. Smart,1 Robin Patel,2 and Chella S. David1*

Department of Immunology,1 Divisions of Infectious Diseases and Clinical Microbiology, Mayo Clinic College of Medicine, Rochester, Minnesota 559052

Received 26 April 2006/ Returned for modification 26 June 2006/ Accepted 3 July 2006

Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the external eye. Using human leukocyte antigen class II transgenic mice, we show for the first time that conjunctival exposure to SEB can cause robust systemic immune activation.

* Corresponding author. Mailing address: Department of Immunology, Mayo Clinic College of Medicine, 200 First St., SW, Rochester, MN 55905. Phone: (507) 284-8180. Fax: (507) 266-0981. E-mail: davic4{at}mayo.edu.

Editor: J. T. Barbieri

Infection and Immunity, October 2006, p. 6016-6019, Vol. 74, No. 10
0019-9567/06/$08.00+0     doi:10.1128/IAI.00671-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rajagopalan, G., Tilahun, A. Y., Asmann, Y. W., David, C. S. (2009). Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor. Physiol. Genomics 37: 279-293 [Abstract] [Full Text]  
  • Brosnahan, A. J., Mantz, M. J., Squier, C. A., Peterson, M. L., Schlievert, P. M. (2009). Cytolysins Augment Superantigen Penetration of Stratified Mucosa. J. Immunol. 182: 2364-2373 [Abstract] [Full Text]  
  • Steven, P., Rupp, J., Huttmann, G., Koop, N., Lensing, C., Laqua, H., Gebert, A. (2008). Experimental Induction and Three-Dimensional Two-Photon Imaging of Conjunctiva-Associated Lymphoid Tissue. IOVS 49: 1512-1517 [Abstract] [Full Text]  
  • Nesburn, A. B., Bettahi, I., Dasgupta, G., Chentoufi, A. A., Zhang, X., You, S., Morishige, N., Wahlert, A. J., Brown, D. J., Jester, J. V., Wechsler, S. L., BenMohamed, L. (2007). Functional Foxp3+ CD4+ CD25(Bright+) "Natural" Regulatory T Cells Are Abundant in Rabbit Conjunctiva and Suppress Virus-Specific CD4+ and CD8+ Effector T Cells during Ocular Herpes Infection. J. Virol. 81: 7647-7661 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»