This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Antonelli, L. R. V.
Right arrow Articles by Gollob, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Antonelli, L. R. V.
Right arrow Articles by Gollob, K. J.

 Previous Article  |  Next Article 

Infection and Immunity, November 2006, p. 6317-6323, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00890-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Disparate Immunoregulatory Potentials for Double-Negative (CD4– CD8–) {alpha}ß and {gamma}{delta} T Cells from Human Patients with Cutaneous Leishmaniasis{triangledown}

Lis R. V. Antonelli,1 Walderez O. Dutra,2 Ricardo R. Oliveira,3 Karen C. L. Torres,1 Luiz H. Guimarães,3 Olivia Bacellar,3 and Kenneth J. Gollob1*

Department of Biochemistry and Immunology,1 Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil,2 Immunology Service, Hospital Edgard Santos, UFBA, Salvador, Bahia, Brazil3

Received 6 June 2006/ Returned for modification 18 June 2006/ Accepted 11 August 2006

Although most T lymphocytes express the {alpha}ß T-cell receptor and either CD4 or CD8 molecules, a small population of cells lacking these coreceptors, CD4– CD8– (double negative [DN]) T cells, has been identified in the peripheral immune system of mice and humans. To better understand the role that this population may have in the human immune response against Leishmania spp., a detailed study defining the activation state, cytokine profile, and the heterogeneity of DN T cells bearing {alpha}ß or {gamma}{delta} T-cell receptors was performed with a group of well-defined cutaneous leishmaniasis patients. Strikingly, on average 75% of DN T cells from cutaneous leishmaniasis patients expressed the {alpha}ß T-cell receptor, with the remainder expressing the {gamma}{delta} receptor, while healthy donors displayed the opposite distribution with ~75% of the DN T cells expressing the {gamma}{delta} T-cell receptor. Additionally, {alpha}ß DN T cells from cutaneous leishmaniasis patients are compatible with previous antigen exposure and recent activation. Moreover, while {alpha}ß DN T cells from Leishmania-infected individuals present a proinflammatory cytokine profile, {gamma}{delta} DN T cells express a regulatory profile exemplified by interleukin-10 production. The balance between these subpopulations could allow for the formation of an effective cellular response while limiting its pathogenic potential.

* Corresponding author. Mailing address: UFMG-ICB, Av. Antonio Carlos, 6627 Belo Horizonte, MG, Brazil. Phone: 55-31-3499-2655. Fax: 55-31-3499-2655. E-mail: kjgollob{at}gmail.com.

{triangledown} Published ahead of print on 21 August 2006.

Editor: W. A. Petri, Jr.

Infection and Immunity, November 2006, p. 6317-6323, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00890-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., Harrison, D. G. (2007). Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. JEM 204: 2449-2460 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»