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Infection and Immunity, November 2006, p. 6479-6486, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00855-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells

Feng Dong, Rhonda Flores, Ding Chen, Jianhua Luo, Youmin Zhong, Zhongming Wu, and Guangming Zhong*

Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229

Received 29 May 2006/ Returned for modification 19 July 2006/ Accepted 1 August 2006

Using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by the hypothetical open reading frame Cpn0797 in the cytoplasm of Chlamydia pneumoniae-infected host cells. The anti-Cpn0797 antibodies specifically recognized Cpn0797 protein without cross-reacting with either CPAFcp or Cpn0796, the only two proteins known to be secreted into the host cell cytosol by C. pneumoniae organisms. Thus, Cpn0797 represents the third C. pneumoniae protein secreted into the host cell cytosol experimentally identified so far.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-1169. Fax: (210) 567-0293. E-mail: Zhongg{at}UTHSCSA.edu.

Editor: F. C. Fang

Infection and Immunity, November 2006, p. 6479-6486, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00855-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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