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Infection and Immunity, November 2006, p. 6496-6500, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00806-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens{triangledown}

Anthony L. Keyburn,1,2 Scott A. Sheedy,1,2 Mark E. Ford,1 Mark M. Williamson,3 Milena M. Awad,2 Julian I. Rood,2 and Robert J. Moore1,2*

Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia,1 Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton 3800, Australia,2 Gribbles Veterinary Pathology, Clayton 3168, Australia3

Received 19 May 2006/ Returned for modification 20 June 2006/ Accepted 11 August 2006

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

* Corresponding author. Mailing address: CSIRO Livestock Industries, Private Bag 24, Geelong, Victoria 3220, Australia. Phone: 61 3 5227 5760. Fax: 61 3 5227 5555. E-mail: rob.moore{at}csiro.au.

{triangledown} Published ahead of print on 21 August 2006.

Editor: J. T. Barbieri

Infection and Immunity, November 2006, p. 6496-6500, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00806-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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