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Infection and Immunity, November 2006, p. 6501-6504, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00597-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mice Naturally Resistant to Yersinia pestis {Delta}pgm Strains Commonly Used in Pathogenicity Studies{triangledown}

Yasemin H. K. Congleton,{dagger} Christine R. Wulff, Edward J. Kerschen,{ddagger} and Susan C. Straley*

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky 40536-0298

Received 11 April 2006/ Returned for modification 13 July 2006/ Accepted 15 August 2006

We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent {Delta}pgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536-0298. Phone: (859) 323-6538. Fax: (859) 257-8994. E-mail: scstra01{at}uky.edu.

{triangledown} Published ahead of print on 5 September 2006.

Editor: V. J. DiRita

{dagger} Present address: Bluegrass Community & Technical College, Cooper Drive, Lexington, KY 40506.

{ddagger} Present address: The Blood Center of Southeastern Wisconsin, Inc., 638 N. 18th Street, P.O. Box 2178, Milwaukee, WI 53201-2178.

Infection and Immunity, November 2006, p. 6501-6504, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00597-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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