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Infection and Immunity, November 2006, p. 6505-6508, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00779-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Serologic Evidence for Effective Production of Cytolysin A in Salmonella enterica Serovars Typhi and Paratyphi A during Human Infection{triangledown}

Christine von Rhein, Klaus-Peter Hunfeld, and Albrecht Ludwig*

Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany

Received 15 May 2006/ Returned for modification 25 July 2006/ Accepted 11 August 2006

ClyASTy and ClyASPaA are closely related pore-forming cytolysins of Salmonella enterica serovars Typhi and Paratyphi A whose expression is strongly repressed under standard in vitro growth conditions. We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. Phone: 49 69 6301 7165. Fax: 49 69 6301 5767. E-mail: albrecht.ludwig{at}em.uni-frankfurt.de.

{triangledown} Published ahead of print on 21 August 2006.

Editor: J. T. Barbieri

Infection and Immunity, November 2006, p. 6505-6508, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00779-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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