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 Previous Article

Infection and Immunity, November 2006, p. 6509-6512, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00740-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The dbpBA Locus of Borrelia burgdorferi Is Not Essential for Infection of Mice{triangledown}

Yanlin Shi, Qilong Xu, Sunita V. Seemanapalli, Kristy McShan, and Fang Ting Liang*

Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803

Received 8 May 2006/ Returned for modification 26 June 2006/ Accepted 22 August 2006

The Lyme disease spirochete Borrelia burgdorferi expresses a broad array of adhesive molecules, including the decorin-binding proteins A and B (DbpA and DbpB), which are believed to play important roles in mammalian infection. The dbpBA locus was deleted; resulting mutants were able to infect both immunodeficient and immunocompetent mice, indicating that neither DbpA nor DbpB is essential for the infection of mammals, although the DbpAB deficiency may significantly attenuate infectivity potential.

* Corresponding author. Mailing address: Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803. Phone: (225) 578-9699. Fax: (225) 578-9701. E-mail: fliang{at}vetmed.lsu.edu.

{triangledown} Published ahead of print on 5 September 2006.

Editor: J. T. Barbieri

Infection and Immunity, November 2006, p. 6509-6512, Vol. 74, No. 11
0019-9567/06/$08.00+0     doi:10.1128/IAI.00740-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Weening, E. H., Parveen, N., Trzeciakowski, J. P., Leong, J. M., Hook, M., Skare, J. T. (2008). Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection. Infect. Immun. 76: 5694-5705 [Abstract] [Full Text]  
  • Shi, Y., Xu, Q., McShan, K., Liang, F. T. (2008). Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi. Infect. Immun. 76: 1239-1246 [Abstract] [Full Text]  
  • Xu, Q., Seemanaplli, S. V., McShan, K., Liang, F. T. (2007). Increasing the Interaction of Borrelia burgdorferi with Decorin Significantly Reduces the 50 Percent Infectious Dose and Severely Impairs Dissemination. Infect. Immun. 75: 4272-4281 [Abstract] [Full Text]  
  • Xu, Q., Seemanapalli, S. V., Reif, K. E., Brown, C. R., Liang, F. T. (2007). Increasing the Recruitment of Neutrophils to the Site of Infection Dramatically Attenuates Borrelia burgdorferi Infectivity. J. Immunol. 178: 5109-5115 [Abstract] [Full Text]  


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