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Infection and Immunity, December 2006, p. 6999-7004, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00435-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Contribution of FliC to Epithelial Cell Invasion by Enterohemorrhagic Escherichia coli O113:H21{triangledown}

Shelley N. Luck,1 Luminita Badea,1 Vicki Bennett-Wood,2 Roy Robins-Browne,2 and Elizabeth L. Hartland1*

Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Melbourne, Victoria 3800,1 Australian Bacterial Pathogenesis Program, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia2

Received 17 March 2006/ Returned for modification 26 April 2006/ Accepted 24 August 2006

Enterohemorrhagic Escherichia coli (EHEC) O113:H21 can invade epithelial cells. In this study, we found that invasion but not adherence was inhibited by anti-FliCH21 specific antibodies. In addition, deletion of fliCH21 from EHEC O113:H21 resulted in an eightfold decrease in invasion that was restored upon transcomplementation with fliCH21 but not with fliCH6. These results suggested that FliC plays an important role in the pathogenesis of infections caused by EHEC O113:H21 by allowing bacteria to penetrate the intestinal epithelium.

* Corresponding author. Mailing address: Department of Microbiology, Monash University, Clayton 3800, Victoria, Australia. Phone: (61) 3 9905 4323. Fax: (61) 3 9905 4811. E-mail: Liz.Hartland{at}med.monash.edu.au.

{triangledown} Published ahead of print on 18 September 2006.

Editor: J. B. Bliska

Infection and Immunity, December 2006, p. 6999-7004, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00435-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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