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Infection and Immunity, December 2006, p. 7005-7009, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.01402-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Surfactant Protein D Increases Fusion of Mycobacterium tuberculosis- Containing Phagosomes with Lysosomes in Human Macrophages{triangledown}

J. Scott Ferguson,1 Jennifer L. Martin,1 Abul K. Azad,3 Travis R. McCarthy,2,3 Peter B. Kang,2,{dagger} Dennis R. Voelker,4 Erika C. Crouch,5 and Larry S. Schlesinger3*

Division of Pulmonary and Critical Care Medicine,1 the Division of Infectious Diseases, Departments of Medicine and Microbiology, Iowa City Veterans Affairs Medical Center and the University of Iowa, Iowa City, Iowa 52242,2 Center for Microbial Interface Biology, Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210,3 The Lord and Taylor Laboratory for Lung Biochemistry, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206,4 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 631105

Received 31 August 2006/ Accepted 23 September 2006

Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N-1147 Doan Hall, 410 W. 10th Ave., Columbus, OH 43210. Phone: (614) 293-0431. Fax: (614) 293-4556. E-mail: larry.schlesinger{at}osumc.edu.

{triangledown} Published ahead of print on 9 October 2006.

Editor: J. L. Flynn

{dagger} Present address: Division of Science and Research Institute, American Dental Association, Chicago, IL 60611.

Infection and Immunity, December 2006, p. 7005-7009, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.01402-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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