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Infection and Immunity, December 2006, p. 7014-7020, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.02063-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Single Nucleotide Polymorphism in the Cytolethal Distending Toxin B Gene Confers Heterogeneity in the Cytotoxicity of Actinobacillus actinomycetemcomitans{triangledown} ,{dagger}

Shuichi Nishikubo,1,2 Masaru Ohara,1 Masae Ikura,1 Katsuo Katayanagi,3 Tamaki Fujiwara,1 Hitoshi Komatsuzawa,1 Hidemi Kurihara,2 and Motoyuki Sugai1*

Departments of Bacteriology,1 Periodontal Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan,2 Department of Mathematical and Life Sciences, Hiroshima University Graduate School of Science, Higashi-Hiroshima 739-8526, Japan3

Received 22 December 2005/ Returned for modification 24 April 2006/ Accepted 12 September 2006

Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 102 to 108 U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.

* Corresponding author. Mailing address: Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan. Phone: 81 82 257 5635. Fax: 81 82 257 5639. E-mail: sugai{at}hiroshima-u.ac.jp.

{triangledown} Published ahead of print on 18 September 2006.

Editor: V. J. DiRita

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Infection and Immunity, December 2006, p. 7014-7020, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.02063-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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