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Infection and Immunity, December 2006, p. 7021-7023, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00977-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Monocyte Chemoattractant Protein 1 Does Not Contribute to Protective Immunity against Pneumococcal Pneumonia{triangledown}

Mark C. Dessing,1,2* Alex F. de Vos,1,2 Sandrine Florquin,3 and Tom van der Poll1,2

Center for Infection and Immunity Amsterdam (CINIMA),1 Center for Experimental and Molecular Medicine,2 Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands3

Received 19 June 2006/ Returned for modification 31 July 2006/ Accepted 7 September 2006

To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.

* Corresponding author. Mailing address: Center for Experimental and Molecular Medicine, Room F0-117, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31205665247. Fax: 31206977192. E-mail: m.c.dessing{at}amc.uva.nl.

{triangledown} Published ahead of print on 18 September 2006.

Editor: J. N. Weiser

Infection and Immunity, December 2006, p. 7021-7023, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00977-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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