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Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 1 of the Lyme Disease Spirochetes Is Expressed in Humans and Induces Antibody Responses Restricted to Nondenatured Structural Determinants

Evelyn Rossmann,^1, Veronique Kitiratschky,^1, Heidelore Hofmann,² Peter Kraiczy,³ Markus M. Simon,⁴ and Reinhard Wallich^1*

Department of Immunology, University of Heidelberg, Heidelberg, Germany,¹ University Clinics for Dermatology and Allergology Am Biederstein, TU Munich, Munich, Germany,² Institute of Medical Microbiology, University Hospital of Frankfurt, Frankfurt, Germany,³ Metschnikoff Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany⁴

Received 30 June 2006/ Returned for modification 8 August 2006/ Accepted 25 August 2006

Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.

Published ahead of print on 25 September 2006.

Editor: D. L. Burns

E.R. and V.K. contributed equally to this study.

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