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Infection and Immunity, December 2006, p. 7029-7031, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00038-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Mouse and Human Cell Activation by N-Dodecanoyl-DL-Homoserine Lactone, a Chromobacterium violaceum Autoinducer{triangledown}

Kazunori Gomi,1* Toshiaki Kikuchi,1 Yutaka Tokue,1 Shigeru Fujimura,1,2 Akiko Uehara,3 Haruhiko Takada,3 Akira Watanabe,1 and Toshihiro Nukiwa1

Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan,1 School of Nursing, Miyagi University, Miyagi, Japan,2 Department of Microbiology and Immunology, Graduate School of Dentistry, Tohoku University, Sendai, Japan3

Received 9 January 2006/ Returned for modification 5 April 2006/ Accepted 5 September 2006

Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C12-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-{kappa}B signaling pathway besides their quorum-sensing role, like 3-oxo-C12-HSL from Pseudomonas aeruginosa.

* Corresponding author. Mailing address: Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-Ku, Sendai 980-8575, Japan. Phone: 81 22 717 8539. Fax: 81 22 717 8549. E-mail: gomi{at}idac.tohoku.ac.jp.

{triangledown} Published ahead of print on 18 September 2006.

Editor: J. L. Flynn

Infection and Immunity, December 2006, p. 7029-7031, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00038-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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