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Infection and Immunity, December 2006, p. 7032-7034, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00828-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Oral Immunization with Acanthamoeba castellanii Mannose-Binding Protein Ameliorates Amoebic Keratitis{triangledown}

M. Garate,1 H. Alizadeh,3 S. Neelam,3 J. Y. Niederkorn,3 and N. Panjwani1,2*

New England Eye Center and Center for Vision Research,1 Departments of Ophthalmology and Biochemistry, Tufts University School of Medicine, Boston, Massachusetts,2 Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas3

Received 22 May 2006/ Accepted 5 September 2006

Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence of elevated levels of anti-MBP immunoglobulin A in the tear fluid of the immunized animals.

* Corresponding author. Mailing address: Department of Ophthalmology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111. Phone: (617) 636-6776. Fax: (617) 636-0348. E-mail: Noorjahan.Panjwani{at}tufts.edu.

{triangledown} Published ahead of print on 18 September 2006.

Editor: W. A. Petri, Jr.

Infection and Immunity, December 2006, p. 7032-7034, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00828-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Alizadeh, H., Neelam, S., Niederkorn, J. Y. (2007). Effect of Immunization with the Mannose-Induced Acanthamoeba Protein and Acanthamoeba Plasminogen Activator in Mitigating Acanthamoeba Keratitis. IOVS 48: 5597-5604 [Abstract] [Full Text]  


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