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Infection and Immunity, December 2006, p. 7035-7039, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00551-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pseudomonas aeruginosa LecB Is Involved in Pilus Biogenesis and Protease IV Activity but Not in Adhesion to Respiratory Mucins{triangledown}

Avinash Sonawane, Jeevan Jyot, and Reuben Ramphal*

Department of Medicine, University of Florida, Gainesville, Florida 32610

Received 4 April 2006/ Returned for modification 25 July 2006/ Accepted 20 September 2006

Pseudomonas aeruginosa expresses two lectins which are implicated in adhesion and biofilm formation. In this study, we demonstrate that P. aeruginosa LecB is involved in pilus biogenesis and proteolytic activity. Moreover, neither lectin was involved in adhesion to human tracheobronchial mucin. We infer that some of the ascribed functions are secondary effects on other systems rather than effects of the lectins themselves.

* Corresponding author. Mailing address: Department of Medicine, College of Medicine, 1600 SW Archer Rd., Gainesville, FL 32610. Phone: (352) 392-2932. Fax: (352) 392-6481. E-mail: ramphr{at}medicine.ufl.edu.

{triangledown} Published ahead of print on 2 October 2006.

Editor: V. J. DiRita

Infection and Immunity, December 2006, p. 7035-7039, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.00551-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chemani, C., Imberty, A., de Bentzmann, S., Pierre, M., Wimmerova, M., Guery, B. P., Faure, K. (2009). Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands. Infect. Immun. 77: 2065-2075 [Abstract] [Full Text]  


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