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Infection and Immunity, December 2006, p. 7040-7042, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.01581-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Alleles 308A and 238A in the Tumor Necrosis Factor Alpha Gene Promoter Do Not Increase the Risk of Severe Malaria in Children with Plasmodium falciparum Infection in Mali{triangledown}

Sandrine Cabantous,1 Ogobara Doumbo,2 Stéphane Ranque,1 Belco Poudiougou,2 Abdoulaye Traore,2 Xunya Hou,1,4 Marouf M. Keita,3 Mahamadou B. Cisse,3 Alain J. Dessein,1 and Sandrine Marquet1*

Immunology and Genetics of Parasitic Diseases, INSERM UMR399, Faculty of Medicine Timone, Université de la Méditerranée, Marseille, France,1 Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali,2 Paediatric Wards, Gabriel Toure Hospital, Bamako, Mali,3 Immunology Department, Hunan Institute of Parasitic Diseases, Yueyang, Hunan Province 41400, China4

Received 27 September 2005/ Returned for modification 16 January 2006/ Accepted 7 September 2006

The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria. Nevertheless, severe malaria was not associated with polymorphisms located at positions –308A and –238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.

* Corresponding author. Mailing address: Immunology and Genetics of Parasitic Diseases, INSERM UMR399, Faculty of Medicine Timone, 27 Blvd. Jean Moulin, Marseille 13385 Cedex 5, France. Phone: 33 4 91 32 44 53. Fax: 33 4 91 79 60 63. E-mail: s.marquet{at}medecine.univ-mrs.fr.

{triangledown} Published ahead of print on 18 September 2006.

Editor: J. F. Urban, Jr.

Infection and Immunity, December 2006, p. 7040-7042, Vol. 74, No. 12
0019-9567/06/$08.00+0     doi:10.1128/IAI.01581-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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