This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pilione, M. R.
Right arrow Articles by Harvill, E. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pilione, M. R.
Right arrow Articles by Harvill, E. T.

 Previous Article  |  Next Article 

Infection and Immunity, February 2006, p. 1043-1049, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1043-1049.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance

Mylisa R. Pilione1,2 and Eric T. Harvill1*

Department of Veterinary and Biomedical Science,1 Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania2

Received 9 September 2005/ Returned for modification 19 October 2005/ Accepted 18 November 2005

Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses. Here, we report an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which contributes to bacterial survival in the lower respiratory tract of the host. The prolonged persistence of B. bronchiseptica that was observed in gamma interferon (IFN-{gamma})–/– mice indicates that the efficient clearance of bacteria from the lower respiratory tract requires not only B cells and antibodies but also IFN-{gamma} production. Our data also suggest that interleukin-10 (IL-10)-producing splenocytes are generated early during infection and that IL-10 inhibits IFN-{gamma}-producing cells and delays the clearance of B. bronchiseptica from the lungs. The TTSS of B. bronchiseptica inhibits the generation of IFN-{gamma}-producing splenocytes and is required for long-term bacterial persistence in the lower respiratory tract in wild-type mice. This suggests that a mechanism involving the modulation of IFN-{gamma} production by the TTSS facilitates B. bronchiseptica survival in the lower respiratory tract.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning, University Park, PA 16802. Phone: (814) 863-8522. Fax: (814) 863-6140. E-mail: eth10{at}psu.edu.

Editor: D. L. Burns

Infection and Immunity, February 2006, p. 1043-1049, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1043-1049.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhang, X., Goebel, E. M., Rodriguez, M. E., Preston, A., Harvill, E. T. (2009). The O Antigen Is a Critical Antigen for the Development of a Protective Immune Response to Bordetella parapertussis. Infect. Immun. 77: 5050-5058 [Abstract] [Full Text]  
  • Buboltz, A. M., Nicholson, T. L., Weyrich, L. S., Harvill, E. T. (2009). Role of the Type III Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica. Infect. Immun. 77: 3969-3977 [Abstract] [Full Text]  
  • Thakar, J., Saadatpour-Moghaddam, A., Harvill, E. T., Albert, R. (2009). Constraint-based network model of pathogen-immune system interactions. J R Soc Interface 6: 599-612 [Abstract] [Full Text]  
  • Sukumar, N., Love, C. F., Conover, M. S., Kock, N. D., Dubey, P., Deora, R. (2009). Active and Passive Immunizations with Bordetella Colonization Factor A Protect Mice against Respiratory Challenge with Bordetella bronchiseptica. Infect. Immun. 77: 885-895 [Abstract] [Full Text]  
  • Cattadori, I. M, Albert, R., Boag, B. (2007). Variation in host susceptibility and infectiousness generated by co-infection: the myxoma-Trichostrongylus retortaeformis case in wild rabbits. J R Soc Interface 4: 831-840 [Abstract] [Full Text]  
  • Mann, P., Goebel, E., Barbarich, J., Pilione, M., Kennett, M., Harvill, E. (2007). Use of a Genetically Defined Double Mutant Strain of Bordetella bronchiseptica Lacking Adenylate Cyclase and Type III Secretion as a Live Vaccine. Infect. Immun. 75: 3665-3672 [Abstract] [Full Text]  
  • Parent, M. A., Wilhelm, L. B., Kummer, L. W., Szaba, F. M., Mullarky, I. K., Smiley, S. T. (2006). Gamma Interferon, Tumor Necrosis Factor Alpha, and Nitric Oxide Synthase 2, Key Elements of Cellular Immunity, Perform Critical Protective Functions during Humoral Defense against Lethal Pulmonary Yersinia pestis Infection.. Infect. Immun. 74: 3381-3386 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»