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Infection and Immunity, February 2006, p. 1368-1372, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1368-1372.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Exchange of Lipooligosaccharide Synthesis Genes Creates Potential Guillain-Barré Syndrome-Inducible Strains of Campylobacter jejuni

Vongsavanh Phongsisay, Viraj N. Perera, and Benjamin N. Fry*

Biotechnology and Environmental Biology, School of Applied Sciences, Royal Melbourne Institute of Technology University, Melbourne, Victoria, Australia

Received 16 June 2005/ Returned for modification 1 August 2005/ Accepted 27 October 2005

Human ganglioside-like structures, such as GM1, found on some Campylobacter jejuni strains have been linked to inducing the Guillain-Barré Syndrome (GBS). This study shows that a C. jejuni strain without GM1-like molecules acquired large DNA fragments, including lipooligosaccharide synthesis genes, from a strain expressing GM1-like molecules and consequently transformed into a number of potential GBS-inducible transformants, which exhibited a high degree of genetic and phenotypic diversity.

* Corresponding author. Mailing address: Biotechnology and Environmental Biology, School of Applied Sciences, Bundoora, 3083, RMIT University, Melbourne, Victoria, Australia. Phone: 61-3-9925-7122. Fax: 61-3-9925-7110. E-mail: Ben.Fry{at}rmit.edu.au.

Editor: V. J. DiRita

Infection and Immunity, February 2006, p. 1368-1372, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1368-1372.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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