This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miyamoto, T.
Right arrow Articles by Genco, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyamoto, T.
Right arrow Articles by Genco, C. A.

 Previous Article  |  Next Article 

Infection and Immunity, February 2006, p. 1376-1380, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1376-1380.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pathogen-Accelerated Atherosclerosis Occurs Early after Exposure and Can Be Prevented via Immunization

Takanari Miyamoto,1,2 Hiromichi Yumoto,3,4 Yusuke Takahashi,3,5 Michael Davey,6 Frank C. Gibson III,3 and Caroline Attardo Genco3,6,7*

Department of General Dentistry, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118,1 Department of Dental Public Health, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan,2 Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts 02118,3 Department of Conservative Dentistry, Tokushima University School of Dentistry, Tokushima 770-8504, Japan,4 Department of Oral Microbiology, Kanagawa Dental College, Yokosuka, Kanagawa 238-8580, Japan,5 Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118,6 Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 021187

Received 13 June 2005/ Returned for modification 29 August 2005/ Accepted 2 November 2005

Here we report on early inflammatory events associated with Porphyromonas gingivalis-accelerated atherosclerosis in apolipoprotein E knockout (ApoE–/–) mice. Animals challenged with P. gingivalis presented with increased macrophage infiltration, innate immune marker expression, and atheroma without elevated systemic inflammatory mediators. This early local inflammatory response was prevented in mice immunized with P. gingivalis. We conclude that localized up-regulation of innate immune markers early after infection, rather than systemic inflammation, contributes to pathogen-accelerated atherosclerosis.


* Corresponding author. Mailing address: Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Evans Biomedical Research Center, Room 637, 650 Albany St., Boston, MA 02118. Phone: (617) 414-5305. Fax: (617) 414-5280. E-mail: caroline.genco{at}bmc.org.

Editor: V. J. DiRita


Infection and Immunity, February 2006, p. 1376-1380, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1376-1380.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Loppnow, H., Werdan, K., Buerke, M. (2008). Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms. Innate Immunity 14: 63-87 [Abstract]  
  • Davey, M., Liu, X., Ukai, T., Jain, V., Gudino, C., Gibson, F. C. III, Golenbock, D., Visintin, A., Genco, C. A. (2008). Bacterial Fimbriae Stimulate Proinflammatory Activation in the Endothelium through Distinct TLRs. J. Immunol. 180: 2187-2195 [Abstract] [Full Text]  
  • Lepper, P. M., Schumann, C., Triantafilou, K., Rasche, F. M., Schuster, T., Frank, H., Schneider, E. M., Triantafilou, M., von Eynatten, M. (2007). Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men. J Am Coll Cardiol 50: 25-31 [Abstract] [Full Text]  
  • Ford, P.J., Gemmell, E., Timms, P., Chan, A., Preston, F.M., Seymour, G.J. (2007). Anti-P. gingivalis Response Correlates with Atherosclerosis. JDR 86: 35-40 [Abstract] [Full Text]  
  • Rahmani, M., Cruz, R. P., Granville, D. J., McManus, B. M. (2006). Allograft Vasculopathy Versus Atherosclerosis. Circ. Res. 99: 801-815 [Abstract] [Full Text]