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Infection and Immunity, February 2006, p. 1387-1393, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1387-1393.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of Phase Variation of Type 1 Fimbriae in a Uropathogenic Escherichia coli Cystitis Isolate during Urinary Tract Infection{dagger}

Jennifer A. Snyder,1 Amanda L. Lloyd,2 C. Virginia Lockatell,3 David E. Johnson,3,4 and Harry L. T. Mobley2*

Department of Microbiology and Immunology,1 Division of Infectious Diseases, University of Maryland School of Medicine,3 Department of Veterans Affairs, Baltimore, Maryland 21201,4 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 481092

Received 22 August 2005/ Returned for modification 4 October 2005/ Accepted 4 November 2005

Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 5641 Medical Science Building II, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109. Phone: (734) 763-3531. Fax: (734) 764-3562. E-mail: hmobley{at}umich.edu.

{dagger} Supplemental material for this article may be found at http://iai.asm.org/.

Editor: A. D. O’Brien

Infection and Immunity, February 2006, p. 1387-1393, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1387-1393.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lane, M. C., Simms, A. N., Mobley, H. L. T. (2007). Complex Interplay between Type 1 Fimbrial Expression and Flagellum-Mediated Motility of Uropathogenic Escherichia coli. J. Bacteriol. 189: 5523-5533 [Abstract] [Full Text]  
  • Holden, N., Totsika, M., Dixon, L., Catherwood, K., Gally, D. L. (2007). Regulation of P-Fimbrial Phase Variation Frequencies in Escherichia coli CFT073. Infect. Immun. 75: 3325-3334 [Abstract] [Full Text]  
  • Lloyd, A. L., Rasko, D. A., Mobley, H. L. T. (2007). Defining Genomic Islands and Uropathogen-Specific Genes in Uropathogenic Escherichia coli. J. Bacteriol. 189: 3532-3546 [Abstract] [Full Text]  


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