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Infection and Immunity, February 2006, p. 1398-1402, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1398-1402.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Salmonella enterica Serovar Typhimurium ompS1 and ompS2 Mutants Are Attenuated for Virulence in Mice

Olivia Rodríguez-Morales, Marcos Fernández-Mora, Ismael Hernández-Lucas, Alejandra Vázquez, José Luis Puente, and Edmundo Calva*

Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

Received 18 May 2005/ Returned for modification 1 July 2005/ Accepted 26 October 2005

Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated.

* Corresponding author. Mailing address: Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, México. Phone: (52) (777) 329-1645. Fax: (52) (777) 313-8673. E-mail: ecalva{at}ibt.unam.mx.

Editor: F. C. Fang

Infection and Immunity, February 2006, p. 1398-1402, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1398-1402.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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