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Infection and Immunity, February 2006, p. 1403-1406, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1403-1406.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Killed Candida albicans Yeasts and Hyphae Inhibit Gamma Interferon Release by Murine Natural Killer Cells

Celia Murciano,1 Eva Villamón,1 José-Enrique O'Connor,2 Daniel Gozalbo,1 and M. Luisa Gil1*

Departamento de Microbiología y Ecología, Universitat de València, Valencia, Spain,1 Laboratorio de Citómica, Centro de Investigación "Principe Felipe," Universitat de València, Valencia, Spain2

Received 29 July 2005/ Returned for modification 30 August 2005/ Accepted 26 October 2005

Killed yeasts and hyphae of Candida albicans inhibit gamma interferon secretion by highly purified murine NK cells in response to the Toll-like receptor ligands lipopolysaccharide and zymosan. This effect, which is also observed in the presence of NK-activating cytokines (interleukin-2 [IL-2], IL-12, and IL-15), may represent a novel mechanism of immune evasion that contributes to the virulence of C. albicans.

* Corresponding author. Mailing address: Departamento de Microbiología y Ecología, Facultad de Ciencias Biológicas, Edificio de Investigación, C/ Dr. Moliner 50, 46100 Burjasot, Valencia, Spain. Phone: 34 96 354 30 26. Fax: 34 96 354 32 02. E-mail: m.luisa.gil{at}uv.es.

Editor: A. Casadevall

Infection and Immunity, February 2006, p. 1403-1406, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1403-1406.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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