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Infection and Immunity, February 2006, p. 1407-1411, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1407-1411.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Human Tumor Necrosis Factor is a Chemoattractant for the Parasite Entamoeba histolytica

Samantha Blazquez,1 Christophe Zimmer,2 Ghislaine Guigon,3 Jean-Christophe Olivo-Marin,2 Nancy Guillén,1* and Elisabeth Labruyère1*

Cell Biology of Parasitism Unit, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France,1 Quantitative Image Analysis Unit, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France,2 Public Health Platform, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France3

Received 4 August 2005/ Returned for modification 5 September 2005/ Accepted 27 October 2005

In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging techniques. Our findings enabled us to propose a hitherto unknown role for TNF as a chemokinetic and chemoattractant agent for this parasite.

* Corresponding author. Mailing address: Cell Biology of Parasitism Unit, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France. For N. Guillen: Phone: 33 1 456 88675. Fax: 33 456 88674. E-mail: nguillen{at}pasteur.fr. For E. Labruyère: Phone: 33 1 45 68 86 76. Fax: 33 1 45 68 86 74. E-mail: elabruye@pasteur.fr.

Editor: W. A. Petri, Jr.

Infection and Immunity, February 2006, p. 1407-1411, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1407-1411.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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