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Infection and Immunity, February 2006, p. 1416-1418, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1416-1418.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85A and Mycobacterium bovis BCG

H. Martin Vordermeier,1* Kris Huygen,2 Mahavir Singh,3 R. Glyn Hewinson,1 and Zhou Xing4

TB Research Group, Veterinary Laboratories Agency-Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom,1 Pasteur Institute of Brussels, Brussels, Belgium,2 Lionex Limited, Mascheroder Weg 1, D38124 Braunschweig, Germany,3 Department of Pathology and Molecular Medicine and Division of Infectious Diseases, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada4

Received 1 July 2005/ Returned for modification 23 September 2005/ Accepted 26 October 2005

Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

* Corresponding author. Mailing address: TB Research Group, VLA-Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom. Phone: 44 1932 357 884. Fax: 44 1932 357 260. E-mail: m.vordermeier{at}vla.defra.gsi.gov.uk.

Editor: J. L. Flynn

Infection and Immunity, February 2006, p. 1416-1418, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1416-1418.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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