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Infection and Immunity, February 2006, p. 1425-1430, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1425-1430.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Macrophages Isolated from Chickens Genetically Resistant or Susceptible to Systemic Salmonellosis Show Magnitudinal and Temporal Differential Expression of Cytokines and Chemokines following Salmonella enterica Challenge{dagger}

Paul Wigley,* Scott Hulme, Lisa Rothwell, Nat Bumstead, Pete Kaiser, and Paul Barrow{ddagger},

Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom

Received 4 August 2005/ Returned for modification 12 October 2005/ Accepted 30 November 2005

Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine interleukin-18, upon Salmonella challenge than those from susceptible birds. This suggests the possibility that salmonellosis resistant-line macrophages signal more effectively and rapidly and are more able to induce protective Th1 adaptive responses.

* Corresponding author. Present address: Department of Veterinary Pathology, University of Liverpool, Leahurst, Neston CH64 0SH, United Kingdom. Phone: 44 151 7946193. Fax: 44 151 794255. E-mail: Paul.Wigley{at}liverpool.ac.uk.

{dagger} Sadly, Nat Bumstead passed away during this study. We fondly dedicate this paper to his memory.

Editor: F. C. Fang

{ddagger} Present address: School of Veterinary Medicine and Science, The University of Nottingham, South Bonington, Loughborough, Leicestershire LE12 5RD, United Kingdom.

Infection and Immunity, February 2006, p. 1425-1430, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1425-1430.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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