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 Previous Article

Infection and Immunity, February 2006, p. 1442-1444, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1442-1444.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Clearance of Enteric Salmonella enterica Serovar Typhimurium in Chickens Is Independent of B-Cell Function

Richard K. Beal,1 Claire Powers,1 T. Fred Davison,1 Paul A. Barrow,2 and Adrian L. Smith1*

Divisions of Immunology,1 Microbiology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom2

Received 11 August 2005/ Returned for modification 20 October 2005/ Accepted 22 November 2005

Salmonella enterica serovar Typhimurium colonizes the gut of chickens and is cleared from the intestine within about 3 weeks. Infection induces high levels of specific antibody, but B cells do not play an essential role in clearance of primary infection or in the enhanced clearance after secondary challenge.

* Corresponding author. Mailing address: Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom. Phone: 44 1635 579385. Fax: 44 1635 577263. E-mail: adrian.smith{at}bbsrc.ac.uk.

Editor: F. C. Fang

Infection and Immunity, February 2006, p. 1442-1444, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.1442-1444.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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