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Infection and Immunity, March 2006, p. 1768-1776, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1768-1776.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Twin Arginine Translocation System Is Essential for Virulence of Yersinia pseudotuberculosis

Moa Lavander,1,2 Solveig K. Ericsson,1 Jeanette E. Bröms,1,2 and Åke Forsberg1,2*

Department of Medical Countermeasures, Division of NBC Defense, Swedish Defense Research Agency, SE-901 82 Umeå, Sweden,1 Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden2

Received 13 September 2005/ Returned for modification 24 October 2005/ Accepted 29 December 2005

Yersinia species pathogenic to humans have been extensively characterized with respect to type III secretion and its essential role in virulence. This study concerns the twin arginine translocation (Tat) pathway utilized by gram-negative bacteria to secrete folded proteins across the bacterial inner membrane into the periplasmic compartment. We have shown that the Yersinia Tat system is functional and required for motility and contributes to acid resistance. A Yersinia pseudotuberculosis mutant strain with a disrupted Tat system (tatC) was, however, not affected in in vitro growth or more susceptible to high osmolarity, oxidative stress, or high temperature, nor was it impaired in type III secretion. Interestingly, the tatC mutant was severely attenuated via both the oral and intraperitoneal routes in the systemic mouse infection model and highly impaired in colonization of lymphoid organs like Peyer's patches and the spleen. Our work highlights that Tat secretion plays a key role in the virulence of Y. pseudotuberculosis.

* Corresponding author. Mailing address: Department of Medical Countermeasures, Division of NBC Defense, Swedish Defense Research Agency, SE-901 82 Umeå, Sweden. Phone: 46 90 10 66 60. Fax: 46 90 10 68 03. E-mail: ake.forsberg{at}foi.se.

Editor: J. B. Bliska

Infection and Immunity, March 2006, p. 1768-1776, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1768-1776.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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