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Infection and Immunity, March 2006, p. 1883-1889, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1883-1889.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Hypophysectomy and Neurointermediate Pituitary Lobectomy Reduce Serum Immunoglobulin M (IgM) and IgG and Intestinal IgA Responses to Salmonella enterica Serovar Typhimurium Infection in Rats

Rafael Campos-Rodríguez,1* Andrés Quintanar-Stephano,2 Rosa Adriana Jarillo-Luna,1 Gabriela Oliver-Aguillón,1 Javier Ventura-Juárez,3 Victor Rivera-Aguilar,4 Istvan Berczi,5 and Kalman Kovacs6

Departamento de Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D.F., Mexico,1 Departamento de Fisiología y Farmacología,2 Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico,3 Departamento de Microbiología, UBIPRO, FES-Iztacala, UNAM, Edo. de México, Mexico,4 Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada,5 Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada6

Received 8 July 2005/ Returned for modification 13 September 2005/ Accepted 22 November 2005

The influence of anterior pituitary hormones on the gastrointestinal tract of humans and animals has been reported. Hypophysectomy (HYPOX) in the rat causes atrophy of the intestinal mucosa, reduction of gastric secretion and intestinal absorption, and increased susceptibility to infections. To our knowledge, there are no studies on the humoral immune response of the gut-associated lymphoid tissue after HYPOX. We have reported that decreased secretion of vasopressin and oxytocin due to neurointermediate pituitary lobectomy (NIL) diminishes humoral and cell-mediated immune responses. However, no data have been published on whether NIL can affect intestinal immune responses. We analyzed the effects of HYPOX and NIL on bacterial colonization of the intestinal lumen, Peyer's patches, and spleen as well as the serum immunoglobulin G (IgG) and IgM and specific intestinal IgA levels in response to Salmonella enterica serovar Typhimurium oral infection. Results showed the following: (i) Salmonella serovar Typhimurium was eliminated from the intestinal lumen at the same rate in rats that underwent a sham operation, HYPOX, and NIL; (ii) Salmonella serovar Typhimurium colonization of Peyer's patches and spleen was significantly higher in both HYPOX and NIL rats than in sham-operated rats; (iii) serum IgG and IgM and intestinal IgA against surface proteins of Salmonella serovar Typhimurium were significantly lower in HYPOX and NIL rats than in sham-operated rats; and (iv) compared to NIL rats, higher Peyer's patch and spleen bacterial colonization and decreased IgG, IgM, and IgA production were observed in HYPOX rats. We conclude that hormones from each pituitary lobe affect the systemic and gastrointestinal humoral immune responses through different mechanisms.

* Corresponding author. Mailing address: Department of Biochemistry, School of Medicine, National Polytechnic Institute, Plan de San Luis y Díaz Mirón, Mexico, D.F. CP. 11340, Mexico. Phone: (55)57482002. Fax: (55)57145455. E-mail: citli{at}prodigy.net.mx.

Editor: F. C. Fang

Infection and Immunity, March 2006, p. 1883-1889, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1883-1889.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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