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Infection and Immunity, March 2006, p. 1941-1943, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1941-1943.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Synthesis of Syndecan-1 by Skeletal Muscle Cells Is an Early Response to Infection with Trichinella spiralis but Is Not Essential for Nurse Cell Development

Daniel P. Beiting,1* Pyong Woo Park,2 and Judith A. Appleton1

James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853,1 Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 770302

Received 29 July 2005/ Returned for modification 23 August 2005/ Accepted 23 November 2005

Trichinella spiralis creates a unique intracellular habitat in striated muscle. We report that a proteoglycan, syndecan-1, is induced early in infection yet is not essential for habitat development and exerts a modest influence on the immune response. This report is the first to address the requirement for a specific muscle protein in trichinellosis by using mice deficient in the relevant gene.

* Corresponding author. Mailing address: James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Phone: (607) 256-5647. Fax: (607) 256-5608. E-mail: db225{at}cornell.edu.

Editor: J. F. Urban, Jr.

Infection and Immunity, March 2006, p. 1941-1943, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1941-1943.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Beiting, D. P., Gagliardo, L. F., Hesse, M., Bliss, S. K., Meskill, D., Appleton, J. A. (2007). Coordinated Control of Immunity to Muscle Stage Trichinella spiralis by IL-10, Regulatory T Cells, and TGF-beta. J. Immunol. 178: 1039-1047 [Abstract] [Full Text]  


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