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Infection and Immunity, March 2006, p. 1944-1948, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1944-1948.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A CpG Oligonucleotide Can Protect Mice from a Low Aerosol Challenge Dose of Burkholderia mallei

David M. Waag,1* Michael J. McCluskie,3 Ningli Zhang,3 and Arthur M. Krieg2

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland,1 Coley Pharmaceutical Group, Wellesley, Massachusetts,2 and Coley Pharmaceutical Group, Ottawa, Canada3

Received 2 September 2005/ Returned for modification 29 October 2005/ Accepted 14 December 2005

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-{gamma})-inducible protein 10, interleukin-12 (IL-12), IFN-{gamma}, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

* Corresponding author. Mailing address: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011. Phone: (301) 619-4893. Fax: (301) 619-2152. E-mail: david.waag{at}amedd.army.mil.

Editor: J. T. Barbieri

Infection and Immunity, March 2006, p. 1944-1948, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1944-1948.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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