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Infection and Immunity, March 2006, p. 1958-1961, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1958-1961.2006

Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge

Sylvia R. Treviño,1 Amy R. Permenter,1 Marilyn J. England,1 Narayanan Parthasarathy,1 Paul H. Gibbs,2 David M. Waag,1* and Tran C. Chanh1,2

Division of Bacteriology,1 Headquarters, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 217022

Received 16 August 2005/ Returned for modification 13 September 2005/ Accepted 27 November 2005

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.

* Corresponding author. Mailing address: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5001. Phone: (301) 619-4893. Fax: (301) 619-2152. E-mail: david.waag{at}det.amedd.army.mil.

Editor: J. B. Bliska

Infection and Immunity, March 2006, p. 1958-1961, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1958-1961.2006




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