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Infection and Immunity, March 2006, p. 1973-1976, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1973-1976.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Requirement of norD for Brucella suis Virulence in a Murine Model of In Vitro and In Vivo Infection

Séverine Loisel-Meyer,1 Maria Pilar Jiménez de Bagüés,2 Eugénie Bassères,1 Jacques Dornand,1 Stephan Köhler,1 Jean-Pierre Liautard,1 and Véronique Jubier-Maurin1*

Institut National de la Santé et de la Recherche Médicale, U431, Université Montpellier II, Montpellier, F-34095 France,1 Unidad de Sanidad Animal, CITA, Gobierno de Aragon, AP. 727, 50080 Zaragoza, Spain2

Received 7 July 2005/ Returned for modification 16 December 2005/ Accepted 17 December 2005

A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication within nitric oxide-producing murine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence.

* Corresponding author. Mailing address: INSERM U431, Université Montpellier II, Place E. Bataillon, CC100, 34095 Montpellier Cedex 05, France. Phone: (33) 4 67 14 42 38. Fax: (33) 4 67 14 33 38. E-mail: v-maurin{at}univ-montp2.fr.

Editor: D. L. Burns

Infection and Immunity, March 2006, p. 1973-1976, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1973-1976.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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