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Infection and Immunity, March 2006, p. 1977-1983, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1977-1983.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Commensal Bacteria Influence Escherichia coli O157:H7 Persistence and Shiga Toxin Production in the Mouse Intestine

Shantini D. Gamage,1 Angela K. Patton,1 Jane E. Strasser,2 Claudia L. Chalk,2 and Alison A. Weiss1*

Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267,1 Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 452292

Received 16 August 2005/ Returned for modification 4 November 2005/ Accepted 9 December 2005

The presence of commensal flora reduced colonization of Escherichia coli O157:H7 and production of Shiga toxin (Stx) in the murine intestine. Stx production was not detected in mice colonized with E. coli that were resistant to the Shiga toxin phage, but it was detected in mice colonized with phage-susceptible E. coli.

* Corresponding author. Mailing address: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0524. Phone: (513) 558-2820. Fax: (513) 558-8474. E-mail: Alison.Weiss{at}uc.edu.

Editor: A. D. O'Brien

Infection and Immunity, March 2006, p. 1977-1983, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1977-1983.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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