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Infection and Immunity, April 2006, p. 2442-2445, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2442-2445.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Wolbachia- and Onchocerca volvulus-Induced Keratitis (River Blindness) Is Dependent on Myeloid Differentiation Factor 88

Illona Gillette-Ferguson,1 Amy G. Hise,2 Yan Sun,1 Eugenia Diaconu,1 Helen F. McGarry,3 Mark J. Taylor,3 and Eric Pearlman1,2*

Department of Ophthalmology,1 Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio,2 Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, United Kingdom3

Received 11 January 2005/ Returned for modification 15 February 2005/ Accepted 9 January 2006

Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.

* Corresponding author. Mailing address: Department of Ophthalmology and Center for Global Health and Diseases, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-7286. Phone: (216) 368-1856. Fax: (216) 368-4825. E-mail: Eric.Pearlman{at}case.edu.

Editor: J. F. Urban, Jr.

Infection and Immunity, April 2006, p. 2442-2445, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2442-2445.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gentil, K., Pearlman, E. (2009). Gamma Interferon and Interleukin-1 Receptor 1 Regulate Neutrophil Recruitment to the Corneal Stroma in a Murine Model of Onchocerca volvulus Keratitis. Infect. Immun. 77: 1606-1612 [Abstract] [Full Text]  
  • Gillette-Ferguson, I., Daehnel, K., Hise, A. G., Sun, Y., Carlson, E., Diaconu, E., McGarry, H. F., Taylor, M. J., Pearlman, E. (2007). Toll-Like Receptor 2 Regulates CXC Chemokine Production and Neutrophil Recruitment to the Cornea in Onchocerca volvulus/ Wolbachia-Induced Keratitis. Infect. Immun. 75: 5908-5915 [Abstract] [Full Text]  
  • Hise, A. G., Daehnel, K., Gillette-Ferguson, I., Cho, E., McGarry, H. F., Taylor, M. J., Golenbock, D. T., Fitzgerald, K. A., Kazura, J. W., Pearlman, E. (2007). Innate Immune Responses to Endosymbiotic Wolbachia Bacteria in Brugia malayi and Onchocerca volvulus Are Dependent on TLR2, TLR6, MyD88, and Mal, but Not TLR4, TRIF, or TRAM. J. Immunol. 178: 1068-1076 [Abstract] [Full Text]  
  • Sun, Y., Hise, A. G., Kalsow, C. M., Pearlman, E. (2006). Staphylococcus aureus-Induced Corneal Inflammation Is Dependent on Toll-Like Receptor 2 and Myeloid Differentiation Factor 88. Infect. Immun. 74: 5325-5332 [Abstract] [Full Text]  


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