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Infection and Immunity, April 2006, p. 2457-2461, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2457-2461.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Posttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor {sigma}L and Roles in Virulence and in Global Regulation of Gene Expression

Elisa Dainese,1,{dagger} Sébastien Rodrigue,2,{dagger} Giovanni Delogu,3 Roberta Provvedi,1 Liette Laflamme,2 Ryszard Brzezinski,4 Giovanni Fadda,3 Issar Smith,5 Luc Gaudreau,2 Giorgio Palù,1 and Riccardo Manganelli1*

Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy,1 Centre de Recherche sur les Mécanismes du Fonctionnement Cellulaire, Université de Sherbrooke, Sherbrooke, Québec, Canada,2 Institute of Microbiology, Catholic University of the Sacred Hearth, Rome, Italy,3 Centre de Valorisation de la Diversité Microbienne, Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada;,4 TB Center, The Public Health Research Institute, Newark, New Jersey5

Received 9 November 2005/ Returned for modification 12 December 2005/ Accepted 23 January 2006

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

* Corresponding author. Mailing address: Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35100 Padova, Italy. Phone: 39 49 827 2366. Fax: 39 49 827 2355. E-mail: riccardo.manganelli{at}unipd.it.

Editor: F. C. Fang

{dagger} E.D. and S.R. contributed equally to this work.

Infection and Immunity, April 2006, p. 2457-2461, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2457-2461.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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