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Infection and Immunity, April 2006, p. 2462-2467, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2462-2467.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Treponema denticola Surface Protease Dentilisin Degrades Interleukin-1ß (IL-1ß), IL-6, and Tumor Necrosis Factor Alpha

Meguru Miyamoto, Kazuyuki Ishihara,* and Katsuji Okuda

Department of Microbiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan

Received 17 September 2005/ Returned for modification 11 November 2005/ Accepted 23 January 2006

Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1ß (IL-1ß), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

* Corresponding author. Mailing address: Department of Microbiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. Phone: 81-043-270-3742. Fax: 81-043-270-3744. E-mail: ishihara{at}tdc.ac.jp.

Editor: J. N. Weiser

Infection and Immunity, April 2006, p. 2462-2467, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2462-2467.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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