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Infection and Immunity, April 2006, p. 2473-2476, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2473-2476.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Adaptive Immunity-Dependent Intestinal Hypermotility Contributes to Host Defense against Giardia spp.

Yolanda S. Andersen,1 Frances D. Gillin,2 and Lars Eckmann1*

Department of Medicine,1 Division of Infectious Diseases, Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 920932

Received 21 September 2005/ Returned for modification 26 October 2005/ Accepted 18 January 2006

Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.

* Corresponding author. Mailing address: Department of Medicine 0665, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0665. Phone: (858) 534-0683. Fax: (858) 822-6454. E-mail: leckmann{at}ucsd.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2006, p. 2473-2476, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2473-2476.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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