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Infection and Immunity, April 2006, p. 2477-2481, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2477-2481.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Distinct Kinetics of Effector CD8+ Cytotoxic T Cells after Infection with Trypanosoma cruzi in Naïve or Vaccinated Mice

Fanny Tzelepis,1 Bruna C. G. de Alencar,1 Marcus L. O. Penido,2 Ricardo T. Gazzinelli,2 Pedro M. Persechini,3 and Mauricio M. Rodrigues1*

Centro Interdisciplinar de Terapia Gênica (CINTERGEN),1 Departmento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo-SP, Brazil, 04044-010,2 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais e Centro de Pesquisas René Rachou, FIOCRUZ, Avenida Augusto de Lima 1715, Barro Preto, 30190-002, Belo Horizonte, Minas Gerais, Brazil,3 Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Bloco G, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, 21941-900, Brazil4

Received 28 November 2005/ Returned for modification 6 January 2006/ Accepted 15 January 2006

The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naïve mice. In contrast, in vaccinated mice, the swift CD8+-T-cell response helps host survival after challenge.

* Corresponding author. Mailing address: CINTERGEN, UNIFESP-Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo-SP, Brazil, 04044-010. Phone and fax: (55) (11) 5571-1095. E-mail: mrodrigues{at}ecb.epm.br.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2006, p. 2477-2481, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2477-2481.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Padilla, A. M., Simpson, L. J., Tarleton, R. L. (2009). Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma cruzi Infection. J. Immunol. 183: 1245-1252 [Abstract] [Full Text]  
  • Silveira, E. L. V., Claser, C., Haolla, F. A. B., Zanella, L. G., Rodrigues, M. M. (2008). Novel Protective Antigens Expressed by Trypanosoma cruzi Amastigotes Provide Immunity to Mice Highly Susceptible to Chagas' Disease. CVI 15: 1292-1300 [Abstract] [Full Text]  
  • Tzelepis, F., de Alencar, B. C. G., Penido, M. L. O., Claser, C., Machado, A. V., Bruna-Romero, O., Gazzinelli, R. T., Rodrigues, M. M. (2008). Infection with Trypanosoma cruzi Restricts the Repertoire of Parasite-Specific CD8+ T Cells Leading to Immunodominance. J. Immunol. 180: 1737-1748 [Abstract] [Full Text]  


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