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Infection and Immunity, April 2006, p. 2482-2486, Vol. 74, No. 4
0019-9567/06/$08.00+0 doi:10.1128/IAI.74.4.2482-2486.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Chlamydiae Modulate Gamma Interferon, Interleukin-1ß, and Tumor Necrosis Factor Alpha Receptor Expression in HeLa Cells
Kari Ann Shirey and
Joseph M. Carlin*
Department of Microbiology, Miami University, Oxford, Ohio
Received 17 November 2005/
Returned for modification 23 December 2005/
Accepted 30 January 2006
Chlamydia psittaci was found to modulate receptor expression for the cytokine receptors that are involved in the synergistic induction of indoleamine dioxygenase in epithelial cells. Increases in receptor expression were seen even with inactivated Chlamydia, suggesting that chlamydial antigens and not products of infection are important for up-regulating cytokine receptor expression.
* Corresponding author. Mailing address: Department of Microbiology, 32 Pearson Hall, Miami University, Oxford, OH 45056. Phone: (513) 529-5422. Fax: (513) 529-2431. E-mail: carlinjm{at}muohio.edu.
Editor: J. D. Clements
Infection and Immunity, April 2006, p. 2482-2486, Vol. 74, No. 4
0019-9567/06/$08.00+0 doi:10.1128/IAI.74.4.2482-2486.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
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Copyright © 2006 by the American Society for Microbiology. All rights reserved.