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Infection and Immunity, April 2006, p. 2482-2486, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2482-2486.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Chlamydiae Modulate Gamma Interferon, Interleukin-1ß, and Tumor Necrosis Factor Alpha Receptor Expression in HeLa Cells

Kari Ann Shirey and Joseph M. Carlin*

Department of Microbiology, Miami University, Oxford, Ohio

Received 17 November 2005/ Returned for modification 23 December 2005/ Accepted 30 January 2006

Chlamydia psittaci was found to modulate receptor expression for the cytokine receptors that are involved in the synergistic induction of indoleamine dioxygenase in epithelial cells. Increases in receptor expression were seen even with inactivated Chlamydia, suggesting that chlamydial antigens and not products of infection are important for up-regulating cytokine receptor expression.


* Corresponding author. Mailing address: Department of Microbiology, 32 Pearson Hall, Miami University, Oxford, OH 45056. Phone: (513) 529-5422. Fax: (513) 529-2431. E-mail: carlinjm{at}muohio.edu.

Editor: J. D. Clements


Infection and Immunity, April 2006, p. 2482-2486, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2482-2486.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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