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Infection and Immunity, April 2006, p. 2487-2490, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2487-2490.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Visceral Leishmania donovani Infection in Interleukin-13–/– Mice

Henry W. Murray,1* Christine W. Tsai,1 Jianguo Liu,2 and Xiaojing Ma2

Departments of Medicine,1 Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 100212

Received 9 December 2005/ Returned for modification 18 January 2006/ Accepted 25 January 2006

Leishmania donovani-infected interleukin-13–/– BALB/c mice showed impaired initial gamma interferon secretion and incomplete granuloma assembly at parasitized liver foci. Nonetheless, control of early parasite replication, resolution of liver infection, and responsiveness to antileishmanial chemotherapy were intact. By itself, interleukin-13 does not appear to materially influence acquired resistance in this intracellular infection.

* Corresponding author. Mailing address: Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021. Phone: (212) 746-6330. Fax: (212) 746-6332. E-mail: hwmurray{at}med.cornell.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2006, p. 2487-2490, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2487-2490.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Basu, R., Bhaumik, S., Haldar, A. K., Naskar, K., De, T., Dana, S. K., Walden, P., Roy, S. (2007). Hybrid Cell Vaccination Resolves Leishmania donovani Infection by Eliciting a Strong CD8+ Cytotoxic T-Lymphocyte Response with Concomitant Suppression of Interleukin-10 (IL-10) but Not IL-4 or IL-13. Infect. Immun. 75: 5956-5966 [Abstract] [Full Text]  


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