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Infection and Immunity, April 2006, p. 2495-2497, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2495-2497.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Protective CD8+ T Cells Induced by Malaria Sporozoites Do Not Undergo Modulation of Interleukin-7 Receptor Expression

Alexandre Morrot,1 Ian A. Cockburn,1 Michael Overstreet,1 Dolores Rodríguez,2 and Fidel Zavala1*

Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205,1 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Campus Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain2

Received 29 November 2005/ Returned for modification 24 January 2006/ Accepted 28 January 2006

CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor {alpha} (IL-7R{alpha}) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7R{alpha} expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205. Phone: (443) 287-1768. Fax: (410) 955-0155. E-mail: fzavala{at}jhsph.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2006, p. 2495-2497, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2495-2497.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Colombetti, S., Levy, F., Chapatte, L. (2009). IL-7 adjuvant treatment enhances long-term tumor antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector. Blood 113: 6629-6637 [Abstract] [Full Text]  
  • Chakravarty, S., Baldeviano, G. C., Overstreet, M. G., Zavala, F. (2008). Effector CD8+ T Lymphocytes against Liver Stages of Plasmodium yoelii Do Not Require Gamma Interferon for Antiparasite Activity. Infect. Immun. 76: 3628-3631 [Abstract] [Full Text]  


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